BIBLIOGRAPHY ON URBAN MALARIA IN NIGERIA Interaction between
BIBLIOGRAPHY ON URBAN MALARIA IN NIGERIA Interaction between acute diarrhoea and falciparurn malaria in Nigerian children. by Sodeinde O; Adeyemo AA; Gbadegesin RA; Olaleye BO; Ajayi-Obe KE; Adernowo OG Department of Paediatrics, University College Hospital, P.M.B., Ibadan, Nigeria. J Diarrhoeal Dis Res (BANGLADESH) Dec 1996, 14 (4) p269-73, ISSN Although both malaria and diarrhoea are major public health problems in developing countries, and separately each has been the subject of intense research, few studies have investigated the interaction between these two conditions. The interaction between diarrhoea and malaria among children aged 4 months to 12 years in two tertiary health-care facilities, University College Hospital, lbadan, and Lagos University Teaching Hospital, Lagos, Nigeria was studied. In lbadan, the prevalence of diarrhoea among the cerebral malaria patients on admission as 11. 7% (7/60) compared to 9.3% (215/2312) among other admissions in 1990 (chi square 0. 16; p = 0.6913). Similarly, no significant difference in the prevalence of diarrhoea was found between the cerebral malaria patients (14.3%) and other patients (16. 1%) seen in Lagos in 1992 (chi square = 0.06, p = 0.81). Thus, cerebral malaria does not seem to be associated with an increased or decreased prevalence of diarrhoea when compared with other conditions. The prevalence of malarial parasitaernia among the 554 diarrhoea patients studied in Ibadan during 1993-1994 was 13.6% compared with 17.9% among the 347 controls (chi square = 3.75, p = 0.053). However, of the children with diarrhoea, malarial parasitaernia was more common among the dehydrated patients (25.4%) than among the well-hydrated patients (11.6%) (chi square = 8.11, p = 0.004). These data suggest that diarrhoea is merely coincidental in severe malaria and conversely, malarial parasitaernia is similarly coincidental in children with acute diarrhoea, although it may be more frequent among dehydrated diarrhoea patients than well-hydrated ones. Malaria in pregnancy: efficacy of a low dose of mefloquine in an area holoendemic for multi-drug resistant Plasmodium falciparum. Okeyeh JN; Lege-Oguntoye L; Ernembolu JO; Agbo M Department of Pharmacology and Clinical Pharmacy, Ahmadu Bello University, Zaria, Nigeria. Ann Trop Med Parasitol (ENGLAND) Jun 1996, 90 (3) p265-8, ISSN Thirty-three pregnant women with pure P. falciparurn parasitaernias (> or 10(3) parasites/microliters blood), were each treated with a single, oral dose (12.5 mg/kg body weight) of mefloquine base (MQ), at Ahmadu Bello University Teaching Hospital, Zaria urban area, Nigeria. All 33 women were aparasitaernic by day 6 post-treatment and none became parasitaemic during the remaining 21 days of observation. Minimal side-effects were reported by the patients. The mean (S.D.) fever- and parasite-clearance times were 48 (17) and 50 (26) h, respectively. In standard microtests in vitro, schizont maturation was inhibited with MQ at 16 pmol/well (3.2 pmol/microliters). These findings indicate that, at least in the study area, semi-immune, pregnant women have high tolerability to relatively low doses of MQ and that such doses are fully effective against the local P. falciparum isolates. Part I-12
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