fever.with gastrointestinal symptoms such as vomiting (Gmail webspace) and diarrhoea.
fever.with gastrointestinal symptoms such as vomiting and diarrhoea. The majority of the adults were comatose (five out of seven) without fever on admission. A review of the English literature on the diagnosis, pathogenesis and management of CM is also presented. The possible reasons of the rising incidence of CM in a holoendemic region such as Nigeria are discussed. Problems of. chloroquine-resistant P. falciparum. in Nigeria: one antimalaria drugs utilisation in metropolitan Calabar. Ezedinachi EN; Ejezie GC; Emeribe AO Department of Medicine, University of Calabar, Nigeria. Cent Afr J Med (ZIMBABWE) Jan 1991, 37 (1) p16-20, ISSN 0008-9176 We studied the antimalarial drugs utilisati.on pattern in urban Calabar, with a view to determining what drugs people take when they have malaria attack and who diagnoses and prescribes the drugs. We used a standard questionnaire data sheet to record the results of the interview carried out by the authors. Malaria symptoms and the drugs consumed were diagnosed and prescribed respectively by self (54pc), qualified medical doctor (32pc) and others including paramedical staff (2pc). The rest (12pc) took traditional remedies. The antimalarial drugs (chloroquine, fansidar, camouqin) were chosen because of their efficacy/popularity (21pc), cheapness (43pc) and availability (34pc). Among those interviewed, only 21.2pc took the adequate curative dose of 25 mg/kg chloroquine for 3 days according to WHO recommendations. Majority of the consumers took their drugs orally, but some (17pc) had chloroquine injections, administered, in some cases, by ill-qualified patient medicine dealer. The results show that there is an association between the level of education and the pattern of remedy sought by the respondents (p less than 0.05). Self- medication was practised significantly more by those with formal education than by those without (p less than 0.05). The trend of consulting patent medicine dealers for prescription decreased with acquisition of more formal education. Conversely, significantly more of the respondents with higher education consulted qualified medical doctors or paramedical staff (P less than 0.05). Two aspects of drug abuse observed here, i.e. the utilisation of sub-curative doses of chloroquine and monotherapy are believed to be two of the factors that lead to the several chloroquine treatment failures which have been recently reported in Calabar, and other areas of Nigeria. Resistance of Plasmodiurn falciparum to sulfadoxine-pyrimethamine combination in semi-immune children in Zaria, northern Nigeria. Lege-Oguntoye L; Adagu SI; Werblinska B; Ogala WN; Slotboom AB Department of Pharmacology, Ahmadu Bello University, Zaria, Nigeria. Trans R Soc Trop Med Hyg (ENGLAND) Jul-Aug 1990, 84 (4) p505-6, ISSN The World Health Organization (WHO) extended field test was employed to assess the in vivo sensitivity of Plasmodium falciparum. to sulfadoxine-pyrimethamine combination in 44 children in Zaria urban area. 36 children (82%) were fully sensitive to the drug and 8 (18%) were resistant at the RI level. 8 parasite isolates were obtained from the children and successfully cultured in vitro using the WHO microtest (mark II) system. Me 8 isolates underwent schizogony at concentrations of 10,000 pmol sulfadoxine/125 pmol pyrimethamine per well, indicating in vitro resistance. Part I-16
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